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Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells.
Yang, Luhan; Grishin, Dennis; Wang, Gang; Aach, John; Zhang, Cheng-Zhong; Chari, Raj; Homsy, Jason; Cai, Xuyu; Zhao, Yue; Fan, Jian-Bing; Seidman, Christine; Seidman, Jonathan; Pu, William; Church, George.
Afiliação
  • Yang L; 1] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, USA.
  • Grishin D; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Wang G; Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
  • Aach J; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Zhang CZ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
  • Chari R; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Homsy J; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Cai X; Illumina, San Diego, California 92122, USA.
  • Zhao Y; Illumina, San Diego, California 92122, USA.
  • Fan JB; Illumina, San Diego, California 92122, USA.
  • Seidman C; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Seidman J; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Pu W; Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
  • Church G; 1] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, USA.
Nat Commun ; 5: 5507, 2014 Nov 26.
Article em En | MEDLINE | ID: mdl-25425480
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptococcus pyogenes / Proteínas de Bactérias / Genoma Humano / Marcação de Genes / Polimorfismo de Nucleotídeo Único / Endonucleases / Células-Tronco Pluripotentes Induzidas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptococcus pyogenes / Proteínas de Bactérias / Genoma Humano / Marcação de Genes / Polimorfismo de Nucleotídeo Único / Endonucleases / Células-Tronco Pluripotentes Induzidas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article