GRASP v2.0: an update on the Genome-Wide Repository of Associations between SNPs and phenotypes.
Nucleic Acids Res
; 43(Database issue): D799-804, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25428361
ABSTRACT
Here, we present an update on the Genome-Wide Repository of Associations between SNPs and Phenotypes (GRASP) database version 2.0 (http//apps.nhlbi.nih.gov/Grasp/Overview.aspx). GRASP is a centralized repository of publically available genome-wide association study (GWAS) results. GRASP v2.0 contains â¼ 8.87 million SNP associations reported in 2082 studies, an increase of â¼ 2.59 million SNP associations (41.4% increase) and 693 studies (48.9% increase) from our previous version. Our goal in developing and maintaining GRASP is to provide a user-friendly means for diverse sets of researchers to query reported SNP associations (P ≤ 0.05) with human traits, including methylation and expression quantitative trait loci (QTL) studies. Therefore, in addition to making the full database available for download, we developed a user-friendly web interface that allows for direct querying of GRASP. We provide details on the use of this web interface and what information may be gleaned from using this interactive option. Additionally, we describe potential uses of GRASP and how the scientific community may benefit from the convenient availability of all SNP association results from GWAS (P ≤ 0.05). We plan to continue updating GRASP with newly published GWAS and increased annotation depth.
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Base de dados:
MEDLINE
Assunto principal:
Fenótipo
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Polimorfismo de Nucleotídeo Único
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Bases de Dados de Ácidos Nucleicos
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Estudo de Associação Genômica Ampla
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article