Stromal androgen receptor roles in the development of normal prostate, benign prostate hyperplasia, and prostate cancer.
Am J Pathol
; 185(2): 293-301, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25432062
ABSTRACT
The prostate is an androgen-sensitive organ that needs proper androgen/androgen receptor (AR) signals for normal development. The progression of prostate diseases, including benign prostate hyperplasia (BPH) and prostate cancer (PCa), also needs proper androgen/AR signals. Tissue recombination studies report that stromal, but not epithelial, AR plays more critical roles via the mesenchymal-epithelial interactions to influence the early process of prostate development. However, in BPH and PCa, much more attention has been focused on epithelial AR roles. However, accumulating evidence indicates that stromal AR is also irreplaceable and plays critical roles in prostate disease progression. Herein, we summarize the roles of stromal AR in the development of normal prostate, BPH, and PCa, with evidence from the recent results of in vitro cell line studies, tissue recombination experiments, and AR knockout animal models. Current evidence suggests that stromal AR may play positive roles to promote BPH and PCa progression, and targeting stromal AR selectively with AR degradation enhancer, ASC-J9, may allow development of better therapies with fewer adverse effects to battle BPH and PCa.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Próstata
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Hiperplasia Prostática
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Neoplasias da Próstata
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Transdução de Sinais
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Receptores Androgênicos
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Proteínas de Neoplasias
Limite:
Animals
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Humans
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Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article