[Exercise and health: from evaluation of health-promoting effects of exercise to exploration of exercise mimetics].
Sheng Li Ke Xue Jin Zhan
; 45(4): 251-6, 2014 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-25434245
ABSTRACT
Regular endurance exercise promotes favorable structure and metabolism adaptations in contracting organ (skeletal muscle) and "far-sited" organ (heart, brain, liver, adipose tissue). Exercise induced skeletal muscle remodeling by activating a series of signaling and transcriptional circuitry (e. g., PPARδ, AMPK, SIRT1 and PGC-1α). In addition, contracting skeletal muscle is an endocrine organ producing and releasing myokines (e. g. IL-6, BDNF and Irisin), which work in a hormone-like fashion, exerting specific endocrine effects on " far-sited" organ. It has been suggested that myokines may contribute to exercise-induced protection against several chronic disease. In this review, we discuss recent discoveries that raise the possibility of synthetically mimicking exercise with pathway-specific drugs to improve health.
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Base de dados:
MEDLINE
Assunto principal:
Exercício Físico
/
Promoção da Saúde
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2014
Tipo de documento:
Article