Short-term add-on tocilizumab and intravenous cyclophosphamide exhibited a remission-inducing effect in a patient with systemic lupus erythematosus with refractory multiorgan involvements including massive pericarditis and glomerulonephritis.
Mod Rheumatol
; 27(3): 529-532, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-25437197
ABSTRACT
We report on a 41-year-old woman with refractory systemic lupus erythematosus with massive pericarditis, macrophage activation syndrome, and glomerulonephritis despite high-dose glucocorticoids and tacrolimus. Tocilizumab dramatically improved pericarditis, and glomerulonephritis was controlled after adding cyclophosphamide. We had to halt tocilizumab and cyclophosphamide due to possible pneumocystis infection after five and three infusions of tocilizumab and intravenous cyclophosphamide, respectively. Nevertheless, no lupus flare had been observed on glucocorticoid monotherapy and enabled further rapid tapering prednisolone.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pericardite
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Ciclofosfamida
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Anticorpos Monoclonais Humanizados
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Glomerulonefrite
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Imunossupressores
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Lúpus Eritematoso Sistêmico
Limite:
Adult
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Female
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article