Extra-articular disease in patients with spondyloarthritis. Baseline characteristics of the spondyloarthritis cohort of the AQUILES study.
Reumatol Clin
; 11(2): 83-9, 2015.
Article
em En, Es
| MEDLINE
| ID: mdl-25441489
ABSTRACT
OBJECTIVES:
To describe the prevalence of extra-articular disease (uveitis, psoriasis and inflammatory bowel disease [IBD]), in a cohort of patients with spondyloarthritis (SpA). PATIENTS ANDMETHODS:
AQUILES is an observational, prospective and multicentric study of three cohorts of patients with one of the following immune-mediated inflammatory diseases (IMID) SpA, psoriasis, or IBD. In the present cohort, patients ≥18 years of age with SpA were enrolled from Rheumatology clinics. The main objective was to assess the coexistence of these diseases and of uveitis, based on the patients' clinical history up to the study entry.RESULTS:
A total of 601 patients with SpA (men 63.1%; women 36.9%) were enrolled. The specific diagnoses were ankylosing spondylitis (55.1%), psoriatic arthritis (25.1%), undifferentiated spondyloarthritis (16.1%), enteropathic arthritis (2.5%), and others (1.3%). In 43.6% (95% CI 39.7-47.6) of the patients, at least one of the three abovementioned diseases was encountered, predominantly psoriasis (prevalence 27.8%, 95% CI 24.4-31.5), uveitis (13.6%, CI 95% 11.1-16.6) and IBD (5.1%, 95% CI 3.7-7.2). In patients with ankylosing spondylitis the proportion of other disease was 25.3% (IBD 3.9%, psoriasis 5.4%, uveitis 19.0%) whilst it was 94.7% in psoriatic arthritis, due to the presence of psoriasis (94.0%). The coexistence of these diseases was associated with age, female gender and the presence of other extra-articular manifestations associated with SpA.CONCLUSIONS:
Extra-articular disease in patients with SpA is common and, in this study, it was associated to age, female gender and the presence of other SpA-related extra-articular manifestations.Palavras-chave
Ankylosing spondyitis; Artritis psoriásica; Enfermedad inflamatoria intestinal; Enfermedad inflamatoria mediada por inmunidad; Espondilitis anquilosante; Espondiloartritis; Immune mediated inflammatory disease; Inflammatory bowel disease; Psoriasis; Psoriatic arthritis; Spondyloarthritis; Uveitis; Uveítis
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Psoríase
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Uveíte
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Doenças Inflamatórias Intestinais
/
Espondilartrite
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
/
Es
Ano de publicação:
2015
Tipo de documento:
Article