Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: an in vitro and in vivo evaluation.

Hong, Chao; Dang, Yang; Lin, Guobei; Yao, Yashu; Li, Guowen; Ji, Guang; Shen, Hongyi; Xie, Yan

Hong, Chao; Dang, Yang; Lin, Guobei; Yao, Yashu; Li, Guowen; Ji, Guang; Shen, Hongyi; Xie, Yan.

Afiliação

Hong C; Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Dang Y; Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Lin G; Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Yao Y; Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China; Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Li G; Pharmacy Department, Shanghai TCM-integrated Hospital, Shanghai 200082, China.
Ji G; Institute of Digestive Diseases, Long Hua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Shen H; Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
Xie Y; Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. Electronic address: rosexie_1996@hotmail.com.

Int J Pharm ; 477(1-2): 251-60, 2014 Dec 30.

Article em En | MEDLINE | ID: mdl-25445518

Assuntos

Sistemas de Liberação de Medicamentos; Flavonoides/administração & dosagem; Flavonoides/química; Nanopartículas/química; Administração Oral; Animais; Disponibilidade Biológica; Varredura Diferencial de Calorimetria; Composição de Medicamentos; Estabilidade de Medicamentos; Flavonoides/sangue; Masculino; Microscopia Eletrônica de Varredura; Estrutura Molecular; Tamanho da Partícula; Ratos Sprague-Dawley; Solubilidade; Propriedades de Superfície; Suspensões; Difração de Raios X

Palavras-chave

Baicalein (PubChem CID: 5281605); Bioavailability; HP-ß-CD (PubChem CID: 44134771); HPMC (PubChem CID: 57503849); Kaempferol (PubChem CID: 5280863); Myricetin; Myricetin (PubChem CID: 5281672); Nanosuspension; Poloxamer (PubChem CID: 24751); Quercetin (PubChem CID: 5280343); Silybin (PubChem CID: 31553); Solubility; Stabilizer; TPGS (PubChem CID: 71406); Vitexin (PubChem CID: 5280441)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Sistemas de Liberação de Medicamentos / Nanopartículas Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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