Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice.

Ding, Jin-Dong; Kelly, Una; Landowski, Michael; Toomey, Christopher B; Groelle, Marybeth; Miller, Chelsey; Smith, Stephanie G; Klingeborn, Mikael; Singhapricha, Terry; Jiang, Haixiang; Frank, Michael M; Bowes Rickman, Catherine

Ding, Jin-Dong; Kelly, Una; Landowski, Michael; Toomey, Christopher B; Groelle, Marybeth; Miller, Chelsey; Smith, Stephanie G; Klingeborn, Mikael; Singhapricha, Terry; Jiang, Haixiang; Frank, Michael M; Bowes Rickman, Catherine.

Afiliação

Ding JD; Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
Kelly U; Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
Landowski M; Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
Toomey CB; Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina.
Groelle M; Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
Miller C; Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
Smith SG; Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
Klingeborn M; Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
Singhapricha T; Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
Jiang H; Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
Frank MM; Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
Bowes Rickman C; Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina. Electronic address: bowes007@duke.edu.

Am J Pathol ; 185(1): 29-42, 2015 Jan.

Article em En | MEDLINE | ID: mdl-25447048

Assuntos

Nefropatias/genética; Degeneração Macular/genética; Doenças Retinianas/genética; Animais; Corioide/patologia; Complemento C3/metabolismo; Fator H do Complemento/genética; Fator H do Complemento/metabolismo; Cruzamentos Genéticos; Eletrorretinografia; Humanos; Nefropatias/patologia; Degeneração Macular/patologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Fenótipo; Retina/metabolismo; Doenças Retinianas/patologia; Epitélio Pigmentado da Retina/patologia; Esclera/patologia; Ovinos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Retinianas / Nefropatias / Degeneração Macular Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google