A novel D-mandelate dehydrogenase used in three-enzyme cascade reaction for highly efficient synthesis of non-natural chiral amino acids.

Fan, Chang-Wei; Xu, Guo-Chao; Ma, Bao-Di; Bai, Yun-Peng; Zhang, Jie; Xu, Jian-He

Fan, Chang-Wei; Xu, Guo-Chao; Ma, Bao-Di; Bai, Yun-Peng; Zhang, Jie; Xu, Jian-He.

Afiliação

Fan CW; Laboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Xu GC; Laboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Ma BD; Laboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Bai YP; Laboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Zhang J; Laboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Xu JH; Laboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address: jianhexu@ecust.edu.cn.

J Biotechnol ; 195: 67-71, 2015 Feb 10.

Article em En | MEDLINE | ID: mdl-25449542

Assuntos

Oxirredutases do Álcool/metabolismo; Proteínas Fúngicas/metabolismo; Glicina/análogos & derivados; Racemases e Epimerases/metabolismo; Oxirredutases do Álcool/química; Oxirredutases do Álcool/isolamento & purificação; Reatores Biológicos; Proteínas Fúngicas/química; Proteínas Fúngicas/isolamento & purificação; Glicina/química; Glicina/metabolismo; Lactobacillus/enzimologia; Ácidos Mandélicos/metabolismo; Pseudomonas putida/enzimologia; Racemases e Epimerases/química; Racemases e Epimerases/isolamento & purificação; Estereoisomerismo

Palavras-chave

Asymmetric synthesis; Cascade reaction; D-Mandelate dehydrogenase; L-Phenylglycine; Process optimization

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Fúngicas / Racemases e Epimerases / Oxirredutases do Álcool / Glicina Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google