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In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent.
Zhang, Tao; Lan, Rongfeng; Chan, Chi-Fai; Law, Ga-Lai; Wong, Wai-Kwok; Wong, Ka-Leung.
Afiliação
  • Zhang T; Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR; Ministry of Education Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal Universi
  • Lan R; Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR;
  • Chan CF; Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR;
  • Law GL; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR klwong@hkbu.edu.hk wkwong@hkbu.edu.hk ga-lai.law@polyu.edu.hk.
  • Wong WK; Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR; klwong@hkbu.edu.hk wkwong@hkbu.edu.hk ga-lai.law@polyu.edu.hk.
  • Wong KL; Department of Chemistry and State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR; klwong@hkbu.edu.hk wkwong@hkbu.edu.hk ga-lai.law@polyu.edu.hk.
Proc Natl Acad Sci U S A ; 111(51): E5492-7, 2014 Dec 23.
Article em En | MEDLINE | ID: mdl-25453097
In this work, we demonstrate a modality of photodynamic therapy (PDT) through the design of our truly dual-functional--PDT and imaging--gadolinium complex (Gd-N), which can target cancer cells specifically. In the light of our design, the PDT drug can specifically localize on the anionic cell membrane of cancer cells in which its laser-excited photoemission signal can be monitored without triggering the phototoxic generation of reactive oxygen species--singlet oxygen--before due excitation. Comprehensive in vitro and in vivo studies had been conducted for the substantiation of the effectiveness of Gd-N as such a tumor-selective PDT photosensitizer. This treatment modality does initiate a new direction in the development of "precision medicine" in line with stem cell and gene therapies as tools in cancer therapy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Gadolínio / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Gadolínio / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article