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Pharmacological characterization of a novel liver X receptor agonist with partial LXRα activity and a favorable window in nonhuman primates.
Kirchgessner, Todd G; Martin, Richard; Sleph, Paul; Grimm, Denise; Liu, Xiaoqin; Lupisella, John; Smalley, James; Narayanan, Rangaraj; Xie, Yinong; Ostrowski, Jacek; Cantor, Glenn H; Mohan, Raju; Kick, Ellen.
Afiliação
  • Kirchgessner TG; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.) tgkakm@gmail.com.
  • Martin R; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.).
  • Sleph P; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.).
  • Grimm D; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.).
  • Liu X; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.).
  • Lupisella J; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.).
  • Smalley J; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.).
  • Narayanan R; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.).
  • Xie Y; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.).
  • Ostrowski J; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.).
  • Cantor GH; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.).
  • Mohan R; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.).
  • Kick E; Bristol-Myers Squibb Research and Development, Bristol-Myers Squibb, Inc., Princeton, New Jersey (T.G.K., P.S., D.G., X.L., J.L., J.S., R.N., J.O., G.H.C., E.K.); and Exelixis, Inc., South San Francisco, California (R.Ma., Y.X., R.Mo.).
J Pharmacol Exp Ther ; 352(2): 305-14, 2015 Feb.
Article em En | MEDLINE | ID: mdl-25467132
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonas / Receptores Nucleares Órfãos / Imidazóis / Fígado / Anticolesterolemiantes Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonas / Receptores Nucleares Órfãos / Imidazóis / Fígado / Anticolesterolemiantes Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article