The synthesis and antiproliferative activities of new arylidene-hydrazinyl-thiazole derivatives.
Int J Mol Sci
; 15(12): 22059-72, 2014 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-25470024
ABSTRACT
New and known arylidene-hydrazinyl-thiazole derivatives have been synthesized by a convenient Hantzsch condensation. All compounds were evaluated for their in vitro cytotoxicity on two carcinoma cell lines, MDA-MB231 and HeLa. Significant antiproliferative activity for 2-(2-benzyliden-hydrazinyl)-4-methylthiazole on both MDA-MB-231 (IC50 3.92 µg/mL) and HeLa (IC50 11.4 µg/mL) cell lines, and for 2-[2-(4-methoxybenzylidene) hydrazinyl]-4-phenylthiazole on HeLa (IC50 11.1 µg/mL) cell line is reported. Electrophoresis experiments showed no plasmid DNA (pTZ57R) cleavage in the presence of the investigated thiazoles.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Hidrazinas
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article