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Design, synthesis and biological evaluation of novel potent MDM2/p53 small-molecule inhibitors.
Ivanenkov, Yan A; Vasilevski, Sergei V; Beloglazkina, Elena K; Kukushkin, Maksim E; Machulkin, Alexey E; Veselov, Mark S; Chufarova, Nina V; Chernyaginab, Elizaveta S; Vanzcool, Anton S; Zyk, Nikolay V; Skvortsov, Dmitry A; Khutornenko, Anastasia A; Rusanov, Alexander L; Tonevitsky, Alexander G; Dontsova, Olga A; Majouga, Alexander G.
Afiliação
  • Ivanenkov YA; ChemDiv, Inc., 6605 Nancy Ridge Drive, San Diego, CA 92121, USA; Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, InstitutskiPereulok 9, Moskovskaya Oblast, Russia; Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia. Electronic address
  • Vasilevski SV; Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia.
  • Beloglazkina EK; Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia; Moscow State University of Mechanical Engineering (MAMI), Moscow, Russia.
  • Kukushkin ME; Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia.
  • Machulkin AE; Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia; Moscow State University of Mechanical Engineering (MAMI), Moscow, Russia.
  • Veselov MS; Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, InstitutskiPereulok 9, Moskovskaya Oblast, Russia. Electronic address: vms@pharmcluster.ru.
  • Chufarova NV; Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, InstitutskiPereulok 9, Moskovskaya Oblast, Russia; National University of Science and Technology MISiS, Moscow 119049, Russia.
  • Chernyaginab ES; Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, InstitutskiPereulok 9, Moskovskaya Oblast, Russia.
  • Vanzcool AS; ChemDiv, Inc., 6605 Nancy Ridge Drive, San Diego, CA 92121, USA.
  • Zyk NV; Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia.
  • Skvortsov DA; Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia.
  • Khutornenko AA; Belozersky Institute, Lomonosov Moscow State University, Leninskie Gory, 1/40, 119992, Moscow, Russia.
  • Rusanov AL; Moscow State University of Mechanical Engineering (MAMI), Moscow, Russia.
  • Tonevitsky AG; SRC Bioclinicum, Ugreshskaya str 2/85, Moscow 115088, Russia; P.A. Hertsen Moscow Research Oncology Institute, 2nd Botkinsky st., 125284 Moscow, Russia.
  • Dontsova OA; Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia; Belozersky Institute, Lomonosov Moscow State University, Leninskie Gory, 1/40, 119992, Moscow, Russia.
  • Majouga AG; Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, 119991 Moscow, Russia; National University of Science and Technology MISiS, Moscow 119049, Russia. Electronic address: majouga@org.chem.msu.ru.
Bioorg Med Chem Lett ; 25(2): 404-9, 2015 Jan 15.
Article em En | MEDLINE | ID: mdl-25479770
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Proteína Supressora de Tumor p53 / Proliferação de Células / Proteínas Proto-Oncogênicas c-mdm2 / Neoplasias / Antineoplásicos Tipo de estudo: Evaluation_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Proteína Supressora de Tumor p53 / Proliferação de Células / Proteínas Proto-Oncogênicas c-mdm2 / Neoplasias / Antineoplásicos Tipo de estudo: Evaluation_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article