Anti-angiogenic activity of Entada africana root.
Nat Prod Res
; 29(16): 1551-6, 2015.
Article
em En
| MEDLINE
| ID: mdl-25482106
ABSTRACT
Entada africana roots are used in African traditional medicine for various diseases including inflammation. This application may be mediated through anti-angiogenic effects. Thus, in this study the anti-angiogenic activity of E. africana root extracts (n-hexane, chloroform, chloroform/methanol and methanol) was preliminarily evaluated by the quantitative determination of endogenous alkaline phosphatase in zebrafish embryos. A bioactivity-guided fractionation of chloroform/methanol extract yielded apigenin and robinetin as the main constituents from the most active fractions. In addition, a marked reduction on capillary formation was evidenced in chick chorioallantoic membrane after treatment with the active fractions or isolated compounds. Results obtained in this study suggest that the anti-angiogenic effects of E. africana root may account for its use in inflammatory diseases and other related pathological conditions.
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Raízes de Plantas
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Inibidores da Angiogênese
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Fabaceae
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article