Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer.
RNA Biol
; 11(11): 1347-54, 2014.
Article
em En
| MEDLINE
| ID: mdl-25483038
Palavras-chave
3'UTR, 3' untranslated region; 5-Aza-dC, 5-aza-2'-deoxycytidine; CGIs, CpG islands; DNA methylation; E2F1, E2F transcription factor 1; FOXO, forkhead box O; HIC1, hypermethylated in cancer 1; LXR, liver X receptor; MicroRNA; MyoD, myogenic differentiation 1; NAD, nicotinamide adenine dinucleotide; NF-κB, nuclear factor kappa-B; OVCA1, ovarian cancer-associated gene 1 protein; OVCA2, ovarian cancer-associated gene 2 protein; PARP, poly(ADP-ribose) polymerase-1; PGC-1α, peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; PUMA, p53-upregulated modulator of apoptosis; SIRT1; SIRT1, sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); SMG6, smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans); Sir2, Silent information regulator 2; cancer; epigenetics; p53, protein 53; pri-miRNA, primary miRNA
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regulação Neoplásica da Expressão Gênica
/
Perfilação da Expressão Gênica
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MicroRNAs
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Sirtuína 1
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article