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Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis.
Crane, Justin D; Palanivel, Rengasamy; Mottillo, Emilio P; Bujak, Adam L; Wang, Huaqing; Ford, Rebecca J; Collins, Andrew; Blümer, Regje M; Fullerton, Morgan D; Yabut, Julian M; Kim, Janice J; Ghia, Jean-Eric; Hamza, Shereen M; Morrison, Katherine M; Schertzer, Jonathan D; Dyck, Jason R B; Khan, Waliul I; Steinberg, Gregory R.
Afiliação
  • Crane JD; 1] Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
  • Palanivel R; 1] Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [2] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [3] Department of Pathology and Molecular Medicine, McMaster University, Hami
  • Mottillo EP; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Bujak AL; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Wang H; 1] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Ford RJ; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Collins A; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Blümer RM; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Fullerton MD; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Yabut JM; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Kim JJ; 1] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Ghia JE; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
  • Hamza SM; Cardiovascular Research Centre, Alberta Diabetes Institute, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
  • Morrison KM; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
  • Schertzer JD; 1] Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. [2] Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Dyck JR; Cardiovascular Research Centre, Alberta Diabetes Institute, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
  • Khan WI; 1] Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [2] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
  • Steinberg GR; 1] Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [2] Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Nat Med ; 21(2): 166-72, 2015 Feb.
Article em En | MEDLINE | ID: mdl-25485911
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triptofano Hidroxilase / Tecido Adiposo Marrom / Resistência à Insulina / Serotonina / Termogênese / Proteínas Mitocondriais / Hepatopatia Gordurosa não Alcoólica / Canais Iônicos / Obesidade Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triptofano Hidroxilase / Tecido Adiposo Marrom / Resistência à Insulina / Serotonina / Termogênese / Proteínas Mitocondriais / Hepatopatia Gordurosa não Alcoólica / Canais Iônicos / Obesidade Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article