[Dependence of the efficiency of cell growth on biosynthetic medical materials on the microstructure of their surface].

ABSTRACT

The efficiency of a novel class of biosynthetic wound dressings in wich natural and synthetic polymeric components are not arranged in layers but are in a unified structure, i. e., form a new composite material, has been studied. In particular, we tried to determine whether the interactions of dressing surface with cells of the injured tissue and/or culture grown in vitro depend on the microstructure of the surface. The efficiency of cell growth was considered in terms of the stimulation of cell growth. The microstructure of the surface was examined using the scanning electron microscopy at high resolution. The results of the study have shown that the structure of biosynthetic dressings depends on the variations in the composition and the ratio of the components. The role of the microstructure of the dressing in the effectiveness has been demonstrated. The factors which have the most significant effect on the regenerating properties of the wound dressings have been revealed.