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Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.
Toy, Pearl; Bacchetti, Peter; Grimes, Barbara; Gajic, Ognjen; Murphy, Edward L; Winters, Jeffrey L; Gropper, Michael A; Hubmayr, Rolf D; Matthay, Michael A; Wilson, Gregory; Koenigsberg, Monique; Lee, Deanna C; Hirschler, Nora V; Lowell, Clifford A; Schuller, Randy M; Gandhi, Manish J; Norris, Philip J; Mair, David C; Sanchez Rosen, Rosa; Looney, Mark R.
Afiliação
  • Toy P; Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California.
  • Bacchetti P; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California.
  • Grimes B; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California.
  • Gajic O; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.
  • Murphy EL; Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California.
  • Winters JL; Blood Systems Research Institute, San Francisco, California.
  • Gropper MA; Division of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota.
  • Hubmayr RD; Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California.
  • Matthay MA; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.
  • Wilson G; Department of Medicine, University of California at San Francisco, San Francisco, California.
  • Koenigsberg M; Department of Anesthesia, Mayo Clinic, Rochester, Minnesota.
  • Lee DC; Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California.
  • Hirschler NV; Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California.
  • Lowell CA; Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California.
  • Schuller RM; Blood Centers of the Pacific, San Francisco, California.
  • Gandhi MJ; Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California.
  • Norris PJ; American Red Cross Neutrophil Reference Laboratory, North Central Blood Services, St Paul, Minnesota.
  • Mair DC; Division of Transfusion Medicine, Mayo Clinic, Rochester, Minnesota.
  • Sanchez Rosen R; Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California.
  • Looney MR; Blood Systems Research Institute, San Francisco, California.
Transfusion ; 55(5): 947-52, 2015 May.
Article em En | MEDLINE | ID: mdl-25488517
BACKGROUND: Possible transfusion-related acute lung injury (pTRALI) cases by definition have a clear temporal relationship to an alternative recipient risk factor for acute respiratory distress syndrome (ARDS). We questioned whether transfusion factors are important for the development of pTRALI. STUDY DESIGN AND METHODS: In this nested case-control study, we prospectively identified 145 consecutive patients with pTRALI and randomly selected 163 transfused controls over a 4-year period at the University of California at San Francisco and the Mayo Clinic (Rochester, Minnesota). RESULTS: For pTRALI, we found evidence against transfusion being important: receipt of plasma from female donors (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.29-2.3; p = 0.70), total number of units transfused (OR, 0.99; 95% CI, 0.89-1.10; p = 0.86), and number of red blood cell and whole blood units transfused (OR, 0.78; 95% CI, 0.59-1.03; p = 0.079). In contrast, we found that risk for pTRALI was associated with additional recipient factors: chronic alcohol abuse (OR, 12.5; 95% CI, 2.8-55; p < 0.001), current smoker (OR, 4.2; 95% CI, 1.67-10.8; p = 0.0024), shock before transfusion (OR, 4.6; 95% CI, 2.0-10.7; p < 0.001), and positive fluid balance before transfusion (OR, 1.32/L; 95% CI, 1.20-1.44; p < 0.001). CONCLUSION: Recipient risk factors for ARDS rather than transfusion risk factors predominate in pTRALI.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesão Pulmonar Aguda / Reação Transfusional Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesão Pulmonar Aguda / Reação Transfusional Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article