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Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids.
Topletz, Ariel R; Tripathy, Sasmita; Foti, Robert S; Shimshoni, Jakob A; Nelson, Wendel L; Isoherranen, Nina.
Afiliação
  • Topletz AR; Departments of Pharmaceutics (A.R.T., S.T., J.A.S., N.I.) and Medicinal Chemistry (W.L.N.), University of Washington, Seattle, Washington; and Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (R.S.F.).
  • Tripathy S; Departments of Pharmaceutics (A.R.T., S.T., J.A.S., N.I.) and Medicinal Chemistry (W.L.N.), University of Washington, Seattle, Washington; and Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (R.S.F.).
  • Foti RS; Departments of Pharmaceutics (A.R.T., S.T., J.A.S., N.I.) and Medicinal Chemistry (W.L.N.), University of Washington, Seattle, Washington; and Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (R.S.F.).
  • Shimshoni JA; Departments of Pharmaceutics (A.R.T., S.T., J.A.S., N.I.) and Medicinal Chemistry (W.L.N.), University of Washington, Seattle, Washington; and Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (R.S.F.).
  • Nelson WL; Departments of Pharmaceutics (A.R.T., S.T., J.A.S., N.I.) and Medicinal Chemistry (W.L.N.), University of Washington, Seattle, Washington; and Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (R.S.F.).
  • Isoherranen N; Departments of Pharmaceutics (A.R.T., S.T., J.A.S., N.I.) and Medicinal Chemistry (W.L.N.), University of Washington, Seattle, Washington; and Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Seattle, Washington (R.S.F.) ni2@u.washington.edu.
Mol Pharmacol ; 87(3): 430-41, 2015.
Article em En | MEDLINE | ID: mdl-25492813

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retinoides / Tretinoína / Sistema Enzimático do Citocromo P-450 Limite: Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retinoides / Tretinoína / Sistema Enzimático do Citocromo P-450 Limite: Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article