Gemcitabine and vinorelbine treatment in cutaneous T-cell lymphoma in four patients.
Australas J Dermatol
; 56(4): 294-7, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-25496219
ABSTRACT
Treatment options for advanced stage cutaneous T-cell lymphoma (CTCL) are limited by the their efficacy and side-effects profile. Gemcitabine, a pyrimidine analogue, has been reported to be efficacious in CTCL. Most of the studies published used gemcitabine as a single agent in treating advanced CTCL. Our small case series demonstrated that a combination of gemcitabine and vinorelbine induced partial remission in all four patients with refractory or advanced CTCL, although the effects were not sustained for a long duration (2-6 months). Two patients had neutropenia and one had acute hepatitis, requiring discontinuation of treatment.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Protocolos de Quimioterapia Combinada Antineoplásica
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Linfoma Cutâneo de Células T
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Antineoplásicos
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article