[Advance in studies on antitumor and immunomodulatory effects of wogonin].
Zhongguo Zhong Yao Za Zhi
; 39(16): 3004-9, 2014 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-25509278
ABSTRACT
Wogonin is a kind of natural flavonoid compound. According to findings in the latest studies, wogonin shows a wide range of antitumor effects, with the characteristics of multi-pathway, multi-link and multi-target, such as promoting tumor cell apoptosis through ROS or Ca(2+)-mediated signal paths, enhancing tumor cytotoxicity by TNF-α and TRAIL, blocking tumor cell cycle, inhibiting tumor angiogenesis and resisting cancer synergistically with chemotherapeutic drugs. Moreover, Wogonin could enhance body immune function by enhancing immune cell infiltration, regulating the immune cell phenotype and promoting relevant cytokine secretion. In this paper, the authors summarized the advance in studies on wogonin's antitumor and immunomodulatory effects.
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Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Flavanonas
/
Fatores Imunológicos
/
Neoplasias
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2014
Tipo de documento:
Article