Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol.

Zhang, Chongben; Hwarng, Gwen; Cooper, Daniel E; Grevengoed, Trisha J; Eaton, James M; Natarajan, Viswanathan; Harris, Thurl E; Coleman, Rosalind A

Zhang, Chongben; Hwarng, Gwen; Cooper, Daniel E; Grevengoed, Trisha J; Eaton, James M; Natarajan, Viswanathan; Harris, Thurl E; Coleman, Rosalind A.

Afiliação

Zhang C; From the Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599.
Hwarng G; From the Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599.
Cooper DE; From the Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599.
Grevengoed TJ; From the Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599.
Eaton JM; the Department of Pharmacology, University of Virginia Health System, Charlottesville, Virginia 22908, and.
Natarajan V; the Departments of Pharmacology & Medicine, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612.
Harris TE; the Department of Pharmacology, University of Virginia Health System, Charlottesville, Virginia 22908, and.
Coleman RA; From the Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, rcoleman@unc.edu.

J Biol Chem ; 290(6): 3519-28, 2015 Feb 06.

Article em En | MEDLINE | ID: mdl-25512376

Assuntos

Diglicerídeos/metabolismo; Hepatócitos/metabolismo; Insulina/metabolismo; Ácidos Fosfatídicos/metabolismo; Transdução de Sinais; Animais; Proteínas de Transporte/metabolismo; Células Cultivadas; Diacilglicerol Quinase/genética; Diacilglicerol Quinase/metabolismo; Glicerol-3-Fosfato O-Aciltransferase/genética; Glicerol-3-Fosfato O-Aciltransferase/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Fosfolipase D/genética; Fosfolipase D/metabolismo; Proteína Quinase C/metabolismo; Proteína Companheira de mTOR Insensível à Rapamicina; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

Diacylglycerol Kinase; Glycerol-3-phosphate Acyltransferase; Glycerophospholipid; Insulin Resistance; Mammalian Target of Rapamycin (mTOR); Phospholipase D; Protein Kinase C (PKC)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Fosfatídicos / Transdução de Sinais / Hepatócitos / Diglicerídeos / Insulina Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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