Symptoms of depression impact the course of lung function in adolescents and adults with cystic fibrosis.
BMC Pulm Med
; 14: 205, 2014 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-25515072
ABSTRACT
BACKGROUND:
Epidemiological studies report high rates of depression among patients with cystic fibrosis (CF). Assuming a causal relationship between depression and the progression of CF, our hypothesis is that elevated symptoms of depression would be a predictor of worse lung function after two years.METHODS:
In the context of the TIDES study, 473 German patients with CF (age 12-53 years, FEV1% predicted M = 66.2, range 13-137) completed the Hospital Anxiety and Depression Scale (HADS). Lung function (FEV1% predicted) was assessed at baseline and followed up two years later. Repeated measures analysis was performed involving the level of FEV1% and the level of depressive symptoms at baseline as independent factors and FEV1% at the 2-year follow-up as the dependent variable.RESULTS:
Interaction between lung function and depression at baseline significantly affected the change in lung function at the 2-years observation interval. The largest decline in FEV1% occurred in depressed patients with good lung function at baseline. In contrast, patients without any clinically relevant depressive symptoms and with poor lung function at baseline showed a slight increase two years later.CONCLUSION:
The findings emphasise the need to screen patients with CF for symptoms of depression and to treat co-morbid depression.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibrose Cística
/
Depressão
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article