[Recent development of non-steroidal anti-inflammatory drugs on the neuro-inflammation of Alzheimer's disease].
Yao Xue Xue Bao
; 49(9): 1211-7, 2014 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-25518320
ABSTRACT
Neuropathological, clinical epidemiology and animal models studies provide clear evidence for the activation of neuroinflammation in Alzheimer's disease (AD), and long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) is linked with reduced risk to develop the disease. But the clinical trials got a negative outcome with traditional NSAIDs treating AD. The therapeutic effects of NSAIDs on Alzheimer's disease are still not clear based on the present research. Profound study for anti-inflammatory mechanisms and standardized clinical trials are needed. As cause and effect relationships between neuroinflammation and AD are being worked out, the challenge is how to realize the effect of traditional NSAIDs on treating AD.
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Base de dados:
MEDLINE
Assunto principal:
Anti-Inflamatórios não Esteroides
/
Doença de Alzheimer
/
Inflamação
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2014
Tipo de documento:
Article