Multicomponent strategy to indeno[2,1-c]pyridine and hydroisoquinoline derivatives through cleavage of carboncarbon bond.
J Org Chem
; 80(2): 1025-33, 2015 Jan 16.
Article
em En
| MEDLINE
| ID: mdl-25521750
ABSTRACT
A concise and efficient three-component domino reaction has been developed for the synthesis of polyfunctionalized indenopyridine and hydroisoquinoline derivatives via the cleavage of a CC bond under transition-metal-free conditions. This reaction provides facile access to complex nitrogen-containing heterocycles by simply mixing three common starting materials in EtOH in the presence of 20 mol % NaOH under microwave irradiation conditions.
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Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Carbono
/
Compostos Heterocíclicos
/
Indenos
/
Nitrogênio
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article