[Pro-angiogenic cytokines in systemic sclerosis]. / Wybrane cytokiny proangiogennnew twardzinie ukladowej.
Postepy Hig Med Dosw (Online)
; 68: 1472-82, 2014 Dec 15.
Article
em Pl
| MEDLINE
| ID: mdl-25531711
ABSTRACT
Systemic sclerosis (SSc) is a multifactorial connective tissue disease characterized by excessive and progressive fibrosis along with microvasculopathy due to poor vascular formation and repair. Despite a general increase in many potent angiogenic factors, the vasculopathy compensatory angiogenesis and vasculogenesis are impaired. In this review, we discuss the role of proangiogenic factors--VEGF, PlGF, endoglin, PDGF, endothelin-1, angiopoietins, SDF-1, uPAR--and the paradoxical paucity of an inadequate angiogenic response in SSc.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas da Gravidez
/
Escleroderma Sistêmico
/
Citocinas
/
Endotelina-1
/
Angiopoietinas
/
Quimiocina CXCL12
Limite:
Humans
Idioma:
Pl
Ano de publicação:
2014
Tipo de documento:
Article