Improving the passive permeability of macrocyclic peptides: Balancing permeability with other physicochemical properties.

Thansandote, Praew; Harris, Robert M; Dexter, Hannah L; Simpson, Graham L; Pal, Sandeep; Upton, Richard J; Valko, Klara

Thansandote, Praew; Harris, Robert M; Dexter, Hannah L; Simpson, Graham L; Pal, Sandeep; Upton, Richard J; Valko, Klara.

Afiliação

Thansandote P; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
Harris RM; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
Dexter HL; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
Simpson GL; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK. Electronic address: graham.l.simpson@gsk.com.
Pal S; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
Upton RJ; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
Valko K; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.

Bioorg Med Chem ; 23(2): 322-7, 2015 Jan 15.

Article em En | MEDLINE | ID: mdl-25533323

Assuntos

Peptídeos Cíclicos/metabolismo; Ligação de Hidrogênio; Peptídeos Cíclicos/química; Permeabilidade; Estrutura Terciária de Proteína; Solubilidade; Estereoisomerismo

Palavras-chave

Macrocyclic peptides; Medicinal chemistry; Passive permeability; Physicochemical properties; Proteinprotein interactions; Therapeutic peptides

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos Idioma: En Ano de publicação: 2015 Tipo de documento: Article