Natural inhibitors of PI3K/AKT signaling in breast cancer: emphasis on newly-discovered molecular mechanisms of action.

Safdari, Yaghoub; Khalili, Masoumeh; Ebrahimzadeh, Mohammad Ali; Yazdani, Yaghoub; Farajnia, Safar

Safdari, Yaghoub; Khalili, Masoumeh; Ebrahimzadeh, Mohammad Ali; Yazdani, Yaghoub; Farajnia, Safar.

Afiliação

Safdari Y; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biotechnology, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran. Electronic address: Safdari_14@yahoo.com.
Khalili M; Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran; Student Research Committee, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: mkhalili_ps@yahoo.com.
Ebrahimzadeh MA; Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Yazdani Y; Infectious Diseases Research Center and Laboratory Science Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Farajnia S; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Pharmacol Res ; 93: 1-10, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25533812

Assuntos

Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Neoplasias da Mama/tratamento farmacológico; Inibidores de Fosfoinositídeo-3 Quinase; Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores; Animais; Neoplasias da Mama/metabolismo; Receptores ErbB/metabolismo; Feminino; Humanos; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais

Palavras-chave

AKT; Ascofuranone (PubChem CID: 6434242); BYL-719 (PubChem CID: 56649450); Breast cancer; CDRI 85-287 (PubChem CID: 159508); Fenretinide: (PubChem CID: 5288209); Isoliquiritigenin (PubChem CID: 638278); Natural inhibitors; PI3K; Platycodin D (PubChem CID: 162859); Quercetin (PubChem CID: 5280343); Thymoquinone (PubChem CID:10281); Wogonin (PubChem CID: 5281703)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Proteínas Proto-Oncogênicas c-akt / Inibidores de Fosfoinositídeo-3 Quinase / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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