[Effects of levonorgestrel intrauterine system on the expressions of estrogen receptor, progesterone receptor and insulin-like growth factor-1].
Zhonghua Yi Xue Za Zhi
; 94(35): 2763-5, 2014 Sep 23.
Article
em Zh
| MEDLINE
| ID: mdl-25533985
ABSTRACT
OBJECTIVE:
To explore the effects of levonorgestrel intrauterine system on estrogen receptor (ER) and progesterone receptor (PR), insulin-like growth factor-1 (IGF-1) of endometrial polyps and surrounding endometrial tissue.METHODS:
A total of 250 cases of hysteroscopic resection for endometrial polyps were divided into study group (n = 125) with placement of levonorgestrel intrauterine system after hysteroscopic electroresection and control group (n = 125) without placement. The intraoperative and postoperative expressions of ER, PR and IGF-1 in endometrial biopsy specimens were measured by immunohistochemistry. They were followed up for 2 years to analyze the recurrence of endometrial polyp.RESULTS:
All patients had successful surgery. When intraoperative and postoperative specimens were compared with regards to the expressions of ER, PR and IGF-1, significant differences existed between two groups. During a 2-year follow-up, the recurrence of endometrial polyp was 10.89% in control group versus 0 in study group.CONCLUSION:
Levonorgestrel intrauterine system may inhibit the recurrence and formation of endometrial polyp through lowering the expressions of ER, PR and IGF-1.
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Base de dados:
MEDLINE
Assunto principal:
Levanogestrel
Limite:
Female
/
Humans
Idioma:
Zh
Ano de publicação:
2014
Tipo de documento:
Article