Effect of muramyl peptides and tumor necrosis factor on oxidative responses of human blood phagocytes.
Immunol Lett
; 22(3): 187-92, 1989 Sep.
Article
em En
| MEDLINE
| ID: mdl-2553589
ABSTRACT
Adjuvant muramyl dipeptides enhanced the intracellular oxidative burst induced by phorbol myristate acetate in purified human polymorphonuclear (PMN) cells and in monocytes. A stronger priming effect was obtained when muramyl dipeptide was conjugated to a protein carrier. Recombinant human tumor necrosis factor (TNF) did not modify the level of intracellular NBT reduction in PMA-stimulated PMN, although it slightly increased the secretion of superoxide anion. In contrast, TNF enhanced the intracellular oxidative burst of monocytes even at the concentration of 10 pg/ml. In human PMN only, the combination of TNF and muramyl dipeptide induced a higher oxidative response than each stimulant alone.
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Base de dados:
MEDLINE
Assunto principal:
Fagócitos
/
Acetilmuramil-Alanil-Isoglutamina
/
Fator de Necrose Tumoral alfa
Limite:
Humans
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article