Persistence of furan-induced epigenetic aberrations in the livers of F344 rats.

de Conti, Aline; Kobets, Tetyana; Tryndyak, Volodymyr; Burnett, Sarah D; Han, Tao; Fuscoe, James C; Beland, Frederick A; Doerge, Daniel R; Pogribny, Igor P

de Conti, Aline; Kobets, Tetyana; Tryndyak, Volodymyr; Burnett, Sarah D; Han, Tao; Fuscoe, James C; Beland, Frederick A; Doerge, Daniel R; Pogribny, Igor P.

Afiliação

de Conti A; *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Kobets T; *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Tryndyak V; *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Burnett SD; *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Han T; *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Fuscoe JC; *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Beland FA; *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Doerge DR; *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Pogribny IP; *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079 igor.pogribny@fda.hhs.gov.

Toxicol Sci ; 144(2): 217-26, 2015 Apr.

Article em En | MEDLINE | ID: mdl-25539665

Assuntos

Epigênese Genética; Furanos/toxicidade; Fígado/efeitos dos fármacos; Acetilação; Animais; Dano ao DNA; Perfilação da Expressão Gênica; Histonas/química; Histonas/metabolismo; Lisina/metabolismo; Masculino; Metilação; Ratos; Ratos Endogâmicos F344

Palavras-chave

gene expression profiling; genetic toxicology; liver carcinogenesis; microarrays

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epigênese Genética / Furanos / Fígado Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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