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Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kß.
Schwartz, Sarit; Wongvipat, John; Trigwell, Cath B; Hancox, Urs; Carver, Brett S; Rodrik-Outmezguine, Vanessa; Will, Marie; Yellen, Paige; de Stanchina, Elisa; Baselga, José; Scher, Howard I; Barry, Simon T; Sawyers, Charles L; Chandarlapaty, Sarat; Rosen, Neal.
Afiliação
  • Schwartz S; Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Wongvipat J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Trigwell CB; AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
  • Hancox U; AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
  • Carver BS; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Rodrik-Outmezguine V; Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Will M; Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Yellen P; Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • de Stanchina E; Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Baselga J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Scher HI; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Barry ST; AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
  • Sawyers CL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Chandarlapaty S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA.
  • Rosen N; Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: rosenn@mskcc.org.
Cancer Cell ; 27(1): 109-22, 2015 Jan 12.
Article em En | MEDLINE | ID: mdl-25544636
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Cromonas / Inibidores de Proteínas Quinases / PTEN Fosfo-Hidrolase / Inibidores de Fosfoinositídeo-3 Quinase / Compostos de Anilina / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Cromonas / Inibidores de Proteínas Quinases / PTEN Fosfo-Hidrolase / Inibidores de Fosfoinositídeo-3 Quinase / Compostos de Anilina / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article