G protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neurons.

Connelly, Timothy; Yu, Yiqun; Grosmaitre, Xavier; Wang, Jue; Santarelli, Lindsey C; Savigner, Agnes; Qiao, Xin; Wang, Zhenshan; Storm, Daniel R; Ma, Minghong

Connelly, Timothy; Yu, Yiqun; Grosmaitre, Xavier; Wang, Jue; Santarelli, Lindsey C; Savigner, Agnes; Qiao, Xin; Wang, Zhenshan; Storm, Daniel R; Ma, Minghong.

Afiliação

Connelly T; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;
Yu Y; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;
Grosmaitre X; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; CNRS, Université de Bourgogne, 21000 Dijon, France;
Wang J; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;
Santarelli LC; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;
Savigner A; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;
Qiao X; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;
Wang Z; College of Life Science, Hebei University, Baoding 071002, China; and Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195.
Storm DR; Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195.
Ma M; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; minghong@mail.med.upenn.edu.

Proc Natl Acad Sci U S A ; 112(2): 590-5, 2015 Jan 13.

Article em En | MEDLINE | ID: mdl-25550517

Assuntos

Mecanotransdução Celular/fisiologia; Neurônios Receptores Olfatórios/fisiologia; Receptores Odorantes/fisiologia; Animais; Sinalização do Cálcio; Células HEK293; Humanos; Mecanorreceptores/fisiologia; Mecanotransdução Celular/genética; Camundongos; Camundongos da Linhagem 129; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos DBA; Camundongos Knockout; Camundongos Transgênicos; Mutagênese Sítio-Dirigida; Técnicas de Patch-Clamp; Receptores Odorantes/genética; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Transdução de Sinais/genética; Transdução de Sinais/fisiologia

Palavras-chave

G protein-coupled receptors; heterologous expression; mechanical sensors; mechanotransduction; odorant receptors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Odorantes / Neurônios Receptores Olfatórios / Mecanotransdução Celular Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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