RNA sequencing reveals a unique fusion of the lysine (K)-specific methyltransferase 2A and smooth muscle myosin heavy chain 11 in myelodysplastic syndrome and acute myeloid leukemia.

Sanders, Mathijs A; Kavelaars, François G; Zeilemaker, Annelieke; Al Hinai, Adil S A; Abbas, Saman; Beverloo, H Berna; van Lom, Kirsten; Valk, Peter J M

Sanders, Mathijs A; Kavelaars, François G; Zeilemaker, Annelieke; Al Hinai, Adil S A; Abbas, Saman; Beverloo, H Berna; van Lom, Kirsten; Valk, Peter J M.

Afiliação

Sanders MA; Department of Hematology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
Kavelaars FG; Department of Hematology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
Zeilemaker A; Department of Hematology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
Al Hinai AS; Department of Hematology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
Abbas S; Department of Hematology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
Beverloo HB; Department of Hematology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
van Lom K; Department of Hematology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
Valk PJ; Department of Hematology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands p.valk@erasmusmc.nl.

Haematologica ; 100(1): e1-3, 2015 Jan.

Article em En | MEDLINE | ID: mdl-25552680

Assuntos

Sequenciamento de Nucleotídeos em Larga Escala/métodos; Histona-Lisina N-Metiltransferase/genética; Leucemia Mieloide Aguda/genética; Síndromes Mielodisplásicas/genética; Proteína de Leucina Linfoide-Mieloide/genética; Cadeias Pesadas de Miosina/genética; Proteínas de Fusão Oncogênica/genética; Idoso; Seguimentos; Fusão Gênica; Humanos; Leucemia Mieloide Aguda/patologia; Leucemia Mieloide Aguda/terapia; Síndromes Mielodisplásicas/patologia; Síndromes Mielodisplásicas/terapia; Prognóstico; Análise de Sequência de RNA/métodos

Palavras-chave

KMT2A; MYH11; acute myeloid leukemia; mutations; myelodysplastic syndrome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndromes Mielodisplásicas / Leucemia Mieloide Aguda / Proteínas de Fusão Oncogênica / Histona-Lisina N-Metiltransferase / Cadeias Pesadas de Miosina / Proteína de Leucina Linfoide-Mieloide / Sequenciamento de Nucleotídeos em Larga Escala Tipo de estudo: Observational_studies / Prognostic_studies Limite: Aged / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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