Effect of sinusoidal electromagnetic field on bone mineral density and histomorphometry of rats at different time points.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
; 36(6): 660-7, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25556743
ABSTRACT
OBJECTIVE:
To investigate the effect of 50 Hz 0.1 mT sinusoidal electromagnetic field at different time points on bone mineral density(BMD)and histomorphometry in rats.METHODS:
Totally 50 6-week-old female SD rats were equally randomized into 5 groups control group,45-minute group,90-minute group,180-minute group,and 270-minute group. Except for the control group,the other four groups were given magnetic intervention in the 50-Hz 0.1-mT sinusoidal electromagnetic field for 45 minutes,90 minutes,180 minutes,or 270 minutes,respectively,on a daily basis. After 8 weeks,the total body BMD,femur BMD,and vertebral BMD were measured by dual-energy X-ray absorptiometry. The left tibia and the fifth lumbar vertebrae were separated for bone tissue static and dynamic analyses.RESULTS:
Compared with control group,the 90-minute group and the 180-minute group had significantly different total body BMD(P<0.01,P<0.05),while no such significant difference was seen in the 45-minute group and 270-minute group (P>0.05). The femur,vertebral BMD,serum biochemical markers,and the static parameters of the fifth lumbar vertebrae tissue showed significant differences in the 90-minute group,180-minute group,and 270-minute group(P<0.01),but not in the 45-minute group (P>0.05). As shown by double fluorescent labeling,the distance was sorted in an order of 90-minute group>180-minutes group>270-minute group>45-minutes group>control group.CONCLUSION:
The 50-Hz 0.1-mT sinusoidal electromagnetic field can effectively increase bone mineral density and improve bone morphology;however,the intervention effectiveness differs at different time points,with the best effectiveness seen at 90 minutes.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Densidade Óssea
/
Campos Eletromagnéticos
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article