Glycine reverses 7-chlorokynurenic acid-induced inhibition of [3H]MK-801 binding.
Brain Res
; 504(2): 325-7, 1989 Dec 18.
Article
em En
| MEDLINE
| ID: mdl-2557130
7-Chlorokynurenic acid (7-Cl KYNA) has been reported to attenuate N-methyl-D-aspartate (NMDA) receptor functioning by a potent and selective inhibitory action mediated at the strychnine-insensitive glycine recognition site of the NMDA complex. Here we report that 7-Cl KYNA dose-dependently inhibits [3H]MK-801 binding to the PCP receptor, and that this effect is reversed by addition of glycine. Since [3H]MK-801 binding is a measure of channel activation, our results are consistent with the hypotheses that 7-Cl KYNA exerts its NMDA receptor antagonism by acting at the glycine site, and that activation of the glycine site is required for NMDA channel activity to occur.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Neurotransmissores
/
Dibenzocicloeptenos
/
Glicina
/
Ácido Cinurênico
Limite:
Animals
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article