Cyclin-dependent kinase 5 phosphorylation of familial prion protein mutants exacerbates conversion into amyloid structure.

Rouget, Raphaël; Sharma, Gyanesh; LeBlanc, Andréa C

Rouget, Raphaël; Sharma, Gyanesh; LeBlanc, Andréa C.

Afiliação

Rouget R; From the Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University, Montréal, Québec H3T 1E2, Canada and.
Sharma G; From the Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University, Montréal, Québec H3T 1E2, Canada and Department of Neurology and Neurosurgery, McGill University, 3775 University Street, Montréal, Québec H3A 2B4, Canada.
LeBlanc AC; From the Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University, Montréal, Québec H3T 1E2, Canada and Department of Neurology and Neurosurgery, McGill University, 3775 University Street, Montréal, Québec H3A 2B4, Canada andrea.leblanc@mcgill.ca.

J Biol Chem ; 290(9): 5759-71, 2015 Feb 27.

Article em En | MEDLINE | ID: mdl-25572400

Assuntos

Amiloide/metabolismo; Quinase 5 Dependente de Ciclina/metabolismo; Mutação; Príons/metabolismo; Amiloide/química; Amiloide/ultraestrutura; Benzotiazóis; Western Blotting; Dicroísmo Circular; Humanos; Cinética; Microscopia Eletrônica de Transmissão; Fosforilação; Príons/química; Príons/genética; Serina/metabolismo; Tiazóis/metabolismo

Palavras-chave

Amyloid; Circular Dichroism (CD); Phosphorylation; Prion; Prion Disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Príons / Quinase 5 Dependente de Ciclina / Amiloide / Mutação Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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