C6 ceramide dramatically enhances docetaxel-induced growth inhibition and apoptosis in cultured breast cancer cells: a mechanism study.

Yang, Lan; Zheng, Li-Yun; Tian, Ye; Zhang, Zhi-Qing; Dong, Wan-Li; Wang, Xu-Fen; Zhang, Xiao-Ying; Cao, Cong

Yang, Lan; Zheng, Li-Yun; Tian, Ye; Zhang, Zhi-Qing; Dong, Wan-Li; Wang, Xu-Fen; Zhang, Xiao-Ying; Cao, Cong.

Afiliação

Yang L; Department of Breast Surgery, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Zheng LY; Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Tian Y; Department of Radiotherapy and Oncology, the Second Affiliated Hospital of Soochow University, Suzhou, China.
Zhang ZQ; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215021, China.
Dong WL; Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, China.
Wang XF; Department of Breast Surgery, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Zhang XY; Department of Cardiothoracic Surgery, the Third Affiliated Hospital of Soochow University, Changzhou, China. Electronic address: dryangbosz@163.com.
Cao C; Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215021, China. Electronic address: caocong@suda.edu.cn.

Exp Cell Res ; 332(1): 47-59, 2015 Mar 01.

Article em En | MEDLINE | ID: mdl-25576381

Assuntos

Antineoplásicos/farmacologia; Apoptose; Ceramidas/farmacologia; Taxoides/farmacologia; Adenilato Quinase/metabolismo; Neoplasias da Mama; Sobrevivência Celular/efeitos dos fármacos; Cisplatino/farmacologia; Docetaxel; Sinergismo Farmacológico; Receptores ErbB/metabolismo; Feminino; Células HEK293; Humanos; Ácidos Hidroxâmicos/farmacologia; MAP Quinase Quinase 4/metabolismo; Células MCF-7; Alvo Mecanístico do Complexo 1 de Rapamicina; Complexos Multiproteicos/metabolismo; Paclitaxel/farmacologia; Proteólise; Serina-Treonina Quinases TOR/metabolismo; Vorinostat

Palavras-chave

C6 ceramide; Docetaxel; Metastatic breast cancer; Mitochondrial permeability transition pore; ROS; Signaling transduction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ceramidas / Apoptose / Taxoides / Antineoplásicos Limite: Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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