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Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis.
Pandey, Poomy; Rachagani, Satyanarayana; Das, Srustidhar; Seshacharyulu, Parthasarathy; Sheinin, Yuri; Naslavsky, Naava; Pan, Zenggang; Smith, Brittney L; Peters, Haley L; Radhakrishnan, Prakash; McKenna, Nicole R; Giridharan, Sai Srinivas Panapakkam; Haridas, Dhanya; Kaur, Sukhwinder; Hollingsworth, Michael A; MacDonald, Richard G; Meza, Jane L; Caplan, Steve; Batra, Surinder K; Solheim, Joyce C.
Afiliação
  • Pandey P; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
  • Rachagani S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Das S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Seshacharyulu P; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Sheinin Y; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Naslavsky N; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Pan Z; Department of Pathology, University of Colorado, Aurora, CO, USA.
  • Smith BL; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
  • Peters HL; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
  • Radhakrishnan P; Current addresses: Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston TX, USA.
  • McKenna NR; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
  • Giridharan SS; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
  • Haridas D; Current addresses: School of Medicine, University of Virginia, Charlottesville, VA, USA.
  • Kaur S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Hollingsworth MA; Current addresses: Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
  • MacDonald RG; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Meza JL; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Caplan S; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
  • Batra SK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Solheim JC; Department of Pathology, University of Colorado, Aurora, CO, USA.
Oncotarget ; 6(4): 2064-75, 2015 Feb 10.
Article em En | MEDLINE | ID: mdl-25576918
ABSTRACT
Amyloid precursor-like protein 2 (APLP2) is aberrantly expressed in pancreatic cancer. Here we showed that APLP2 is increased in pancreatic cancer metastases, particularly in metastatic lesions found in the diaphragm and intestine. Examination of matched human primary tumor-liver metastasis pairs showed that 38.1% of the patients had positive APLP2 expression in both the primary tumor and the corresponding liver metastasis. Stable knock-down of APLP2 expression (with inducible shRNA) in pancreatic cancer cells reduced the ability of these cells to migrate and invade. Loss of APLP2 decreased cortical actin and increased intracellular actin filaments in pancreatic cancer cells. Down-regulation of APLP2 decreased the weight and metastasis of orthotopically transplanted pancreatic tumors in nude mice.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Citoesqueleto de Actina / Precursor de Proteína beta-Amiloide / Proliferação de Células / Proteínas do Tecido Nervoso Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Citoesqueleto de Actina / Precursor de Proteína beta-Amiloide / Proliferação de Células / Proteínas do Tecido Nervoso Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article