The indications and efficacy of conventional chemotherapy in primary and recurrent sarcoma.
J Surg Oncol
; 111(5): 622-31, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25581912
ABSTRACT
Conventional chemotherapy can have a favorable impact on the natural history of disease for selected patients with primary high-risk bone and soft-tissue sarcomas. In particular, multidrug regimens are integral to the care of patients with the most aggressive histologies, including Ewing sarcoma, osteosarcoma, and non-pleomorphic rhabdomyosarcoma. Appropriately selected patients with high-risk, clinically localized soft-tissue sarcomas may also benefit from histology-tailored adjuvant or neoadjuvant therapy. For patients with recurrent disease, conventional chemotherapy is frequently the most appropriate first-line therapy; active drugs are discussed at length. Several new promising cytotoxic chemotherapeutic agents are currently under development, including aldoxorubicin, TH-302, and trabectedin.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sarcoma
/
Recidiva Local de Neoplasia
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article