Persistent organic pollutants and promoter hypermethylation of the O(6)-methylguanine-DNA methyltransferase gene.
Biomarkers
; 20(2): 136-42, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25585924
Promoter hypermethylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) DNA repair gene is important during carcinogenesis. We explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), were associated with hypermethylation of the MGMT gene promoter in peripheral leukocytes among 368 Koreans without cancer. Hypermethylation decreased as OCPs increased (Ptrend = 0.02), while PCB concentrations showed an inverted U-shaped association (Pquadratic < 0.01). The prevalence of MGMT promoter hypermethylation was highest within the 2nd quintile of the PCB summary score (28.4%), while it was only 2.7% in the upper 10% score. Chronic exposure to these chemicals may affect methylation of the MGMT promoter, with possibly non-monotonic dose response relationships.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Praguicidas
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Bifenilos Policlorados
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Metilação de DNA
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Hidrocarbonetos Clorados
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Humans
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article