Plasmonic copper sulfide nanocrystals exhibiting near-infrared photothermal and photodynamic therapeutic effects.
ACS Nano
; 9(2): 1788-800, 2015 Feb 24.
Article
em En
| MEDLINE
| ID: mdl-25603353
ABSTRACT
Recently, plasmonic copper sulfide (Cu2-xS) nanocrystals (NCs) have attracted much attention as materials for photothermal therapy (PTT). Previous reports have correlated photoinduced cell death to the photothermal heat mechanism of these NCs, and no evidence of their photodynamic properties has been reported yet. Herein we have prepared physiologically stable near-infrared (NIR) plasmonic copper sulfide NCs and analyzed their photothermal and photodynamic properties, including therapeutic potential in cultured melanoma cells and a murine melanoma model. Interestingly, we observe that, besides a high PTT efficacy, these copper sulfide NCs additionally possess intrinsic NIR induced photodynamic activity, whereupon they generate high levels of reactive oxygen species. Furthermore, in vitro and in vivo acute toxic responses of copper sulfide NCs were also elicited. This study highlights a mechanism of NIR light induced cancer therapy, which could pave the way toward more effective nanotherapeutics.
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Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
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Sulfetos
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Fármacos Fotossensibilizantes
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Cobre
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Nanopartículas
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Raios Infravermelhos
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article