A synaptic vesicle membrane protein is conserved from mammals to Drosophila.
Neuron
; 2(5): 1475-81, 1989 May.
Article
em En
| MEDLINE
| ID: mdl-2560644
ABSTRACT
The structure of synaptobrevin, an intrinsic membrane protein of small synaptic vesicles from mammalian brain, was studied by purification and molecular cloning. Its message in bovine brain encodes a 116 amino acid protein whose sequence reveals it to be the mammalian homolog of Torpedo VAMP-1. Antibody probing demonstrates that the protein is also present in Drosophila, and its Drosophila homolog was cloned. Alignment of the sequences of synaptobrevin/VAMP-1 from the three species shows it to contain four domains, including a highly conserved central region of 63 amino acids that contains 75% invariant residues. The finding that a membrane protein from vertebrate synaptic vesicles is conserved in Drosophila points toward a central role of this protein in neurotransmission and should allow a genetic approach to neurotransmitter release.
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Base de dados:
MEDLINE
Assunto principal:
Vesículas Sinápticas
/
Drosophila melanogaster
/
Mamíferos
/
Proteínas de Membrana
/
Proteínas do Tecido Nervoso
Limite:
Animals
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article