Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa.

Sinxadi, Phumla Z; Leger, Paul D; McIlleron, Helen M; Smith, Peter J; Dave, Joel A; Levitt, Naomi S; Maartens, Gary; Haas, David W

Sinxadi, Phumla Z; Leger, Paul D; McIlleron, Helen M; Smith, Peter J; Dave, Joel A; Levitt, Naomi S; Maartens, Gary; Haas, David W.

Afiliação

Sinxadi PZ; Division of Clinical of Pharmacology, Division of Exercise and Endocrine Metabolism, University of Cape Town, Cape Town, South Africa.
Leger PD; Vanderbilt University Medical Center, Department of Medicine, Nashville, Tennessee, United States of America.
McIlleron HM; Division of Clinical of Pharmacology, Division of Exercise and Endocrine Metabolism, University of Cape Town, Cape Town, South Africa.
Smith PJ; Division of Clinical of Pharmacology, Division of Exercise and Endocrine Metabolism, University of Cape Town, Cape Town, South Africa.
Dave JA; Division of Exercise and Endocrine Metabolism, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Levitt NS; Division of Exercise and Endocrine Metabolism, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Maartens G; Division of Clinical of Pharmacology, Division of Exercise and Endocrine Metabolism, University of Cape Town, Cape Town, South Africa.
Haas DW; Vanderbilt University School of Medicine, Department of Medicine, Nashville, Tennessee, United States of America.

Br J Clin Pharmacol ; 80(1): 146-56, 2015 Jul.

Article em En | MEDLINE | ID: mdl-25611810

Assuntos

Fármacos Anti-HIV/sangue; Fármacos Anti-HIV/farmacocinética; Benzoxazinas/sangue; Benzoxazinas/farmacocinética; Citocromo P-450 CYP2B6/genética; Infecções por HIV/genética; Adolescente; Adulto; Alcinos; Fármacos Anti-HIV/uso terapêutico; Benzoxazinas/uso terapêutico; População Negra/genética; Criança; Pré-Escolar; Receptor Constitutivo de Androstano; Ciclopropanos; Feminino; Genótipo; Infecções por HIV/sangue; Infecções por HIV/tratamento farmacológico; Humanos; Masculino; Pessoa de Meia-Idade; Polimorfismo de Nucleotídeo Único/genética; África do Sul; Adulto Jovem

Palavras-chave

CYP2B6; HIV therapy; South Africa; efavirenz; pharmacogenetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Fármacos Anti-HIV / Benzoxazinas / Citocromo P-450 CYP2B6 Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged País como assunto: Africa Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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