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Supramolecular nanosubstrate-mediated delivery for reprogramming and transdifferentiation of mammalian cells.
Hou, Shuang; Choi, Jin-sil; Chen, Kuan-Ju; Zhang, Yang; Peng, Jinliang; Garcia, Mitch A; Yu, Jue-Hua; Thakore-Shah, Kaushali; Ro, Tracy; Chen, Jie-Fu; Peyda, Parham; Fan, Guoping; Pyle, April D; Wang, Hao; Tseng, Hsian-Rong.
Afiliação
  • Hou S; National Center for Nanoscience and Technology, Beijing, 100190, China.
  • Choi JS; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
  • Chen KJ; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
  • Zhang Y; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
  • Peng J; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
  • Garcia MA; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
  • Yu JH; School of Biomedical Engineering, MED-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200030, China.
  • Thakore-Shah K; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
  • Ro T; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-7088.
  • Chen JF; Molecular Biology Institute, Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 90024, USA.
  • Peyda P; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
  • Fan G; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
  • Pyle AD; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
  • Wang H; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-7088.
  • Tseng HR; Molecular Biology Institute, Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 90024, USA.
Small ; 11(21): 2499-504, 2015 Jun 03.
Article em En | MEDLINE | ID: mdl-25613059
ABSTRACT
Supramolecular nanosubstrate-mediated delivery (SNSMD) leverages the power of molecular self-assembly and a nanostructured substrate platform for the low toxicity, highly efficient co-delivery of biological factors encapsulated in a nanovector. Human fibroblasts are successfully reprogrammed into induced pluripotent stems and transdifferentiated into induced neuronal-like cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Reprogramação Celular / Transdiferenciação Celular / Técnicas de Reprogramação Celular Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Reprogramação Celular / Transdiferenciação Celular / Técnicas de Reprogramação Celular Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article