Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease.

Zabala, Valerie; Tong, Ming; Yu, Rosa; Ramirez, Teresa; Yalcin, Emine B; Balbo, Silvia; Silbermann, Elizabeth; Deochand, Chetram; Nunez, Kavin; Hecht, Stephen; de la Monte, Suzanne M

Zabala, Valerie; Tong, Ming; Yu, Rosa; Ramirez, Teresa; Yalcin, Emine B; Balbo, Silvia; Silbermann, Elizabeth; Deochand, Chetram; Nunez, Kavin; Hecht, Stephen; de la Monte, Suzanne M.

Afiliação

Zabala V; Department of Medicine, Division of Gastroenterology, and The Liver Research Center, Rhode Island Hospital, Providence, RI, USA Department of Molecular Pharmacology and Physiology, Brown University, Providence, RI, USA.
Tong M; Department of Medicine, Division of Gastroenterology, and The Liver Research Center, Rhode Island Hospital, Providence, RI, USA Warren Alpert Medical School of Brown University, Providence, RI, USA.
Yu R; Department of Neuroscience, Brown University, Providence, RI, USA.
Ramirez T; Department of Molecular Pharmacology and Physiology, Brown University, Providence, RI, USA.
Yalcin EB; Department of Medicine, Division of Gastroenterology, and The Liver Research Center, Rhode Island Hospital, Providence, RI, USA Warren Alpert Medical School of Brown University, Providence, RI, USA.
Balbo S; Masonic Cancer Center, University of Minnesota, Cancer and Cardiovascular Research Building, 2231 6th Street SE, Minneapolis, MN 55455, USA.
Silbermann E; Warren Alpert Medical School of Brown University, Providence, RI, USA.
Deochand C; Biotechnology Graduate Program, Brown University, Providence, RI, USA.
Nunez K; Department of Neuroscience, Brown University, Providence, RI, USA.
Hecht S; Masonic Cancer Center, University of Minnesota, Cancer and Cardiovascular Research Building, 2231 6th Street SE, Minneapolis, MN 55455, USA.
de la Monte SM; Department of Medicine, Division of Gastroenterology, and The Liver Research Center, Rhode Island Hospital, Providence, RI, USA Warren Alpert Medical School of Brown University, Providence, RI, USA Departments of Pathology and Neurology, and the Division of Neuropathology, Rhode Island Hospital, Pro

Alcohol Alcohol ; 50(2): 118-31, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25618784

Assuntos

Alcoolismo; Consumo Excessivo de Bebidas Alcoólicas; Carcinógenos/farmacologia; Fígado Gorduroso Alcoólico/patologia; Fígado/efeitos dos fármacos; Nitrosaminas/farmacologia; Animais; Depressores do Sistema Nervoso Central/farmacologia; Depressores do Sistema Nervoso Central/toxicidade; Modelos Animais de Doenças; Retículo Endoplasmático/efeitos dos fármacos; Retículo Endoplasmático/metabolismo; Etanol/farmacologia; Etanol/toxicidade; Fígado Gorduroso Alcoólico/etiologia; Fígado Gorduroso Alcoólico/metabolismo; Hepatócitos/efeitos dos fármacos; Hepatócitos/metabolismo; Hepatócitos/patologia; Insulina/metabolismo; Resistência à Insulina; Fator de Crescimento Insulin-Like I/metabolismo; Fígado/metabolismo; Fígado/patologia; Hepatopatias Alcoólicas/metabolismo; Hepatopatias Alcoólicas/patologia; Mitocôndrias Hepáticas/efeitos dos fármacos; Mitocôndrias Hepáticas/metabolismo; Necrose; Ratos; Ratos Long-Evans; Receptor IGF Tipo 1/metabolismo; Receptor de Insulina/metabolismo; Transdução de Sinais/efeitos dos fármacos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinógenos / Alcoolismo / Fígado Gorduroso Alcoólico / Consumo Excessivo de Bebidas Alcoólicas / Fígado / Nitrosaminas Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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