Poverty-related and neglected diseases - an economic and epidemiological analysis of poverty relatedness and neglect in research and development.
Glob Health Action
; 8: 25818, 2015.
Article
em En
| MEDLINE
| ID: mdl-25623607
ABSTRACT
BACKGROUND:
Economic growth in low- and middle-income countries (LMIC) has raised interest in how disease burden patterns are related to economic development. Meanwhile, poverty-related diseases are considered to be neglected in terms of research and development (R&D).OBJECTIVES:
Developing intuitive and meaningful metrics to measure how different diseases are related to poverty and neglected in the current R&D system.DESIGN:
We measured how diseases are related to economic development with the income relation factor (IRF), defined by the ratio of disability-adjusted life-years (DALYs) per 100,000 inhabitants in LMIC versus that in high-income countries. We calculated the IRF for 291 diseases and injuries and 67 risk factors included in the Global Burden of Disease Study 2010. We measured neglect in R&D with the neglect factor (NF), defined by the ratio of disease burden in DALYs (as percentage of the total global disease burden) and R&D expenditure (as percentage of total global health-related R&D expenditure) for 26 diseases.RESULTS:
The disease burden varies considerably with the level of economic development, shown by the IRF (median 1.38; interquartile range (IQR) 0.79-6.3). Comparison of IRFs from 1990 to 2010 highlights general patterns of the global epidemiological transition. The 26 poverty-related diseases included in our analysis of neglect in R&D are responsible for 13.8% of the global disease burden, but receive only 1.34% of global health-related R&D expenditure. Within this group, the NF varies considerably (median 19; IQR 6-52).CONCLUSIONS:
The IRF is an intuitive and meaningful metric to highlight shifts in global disease burden patterns. A large shortfall exists in global R&D spending for poverty-related and neglected diseases, with strong variations between diseases.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pobreza
/
Desenvolvimento Econômico
/
Saúde Global
/
Países em Desenvolvimento
/
Doenças Negligenciadas
Tipo de estudo:
Etiology_studies
/
Health_economic_evaluation
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article