17-Allylamino-17-Demethoxygeldanamycin and the Enhancement of PS-341-Induced Lung Cancer Cell Death by Blocking the NF-&#954;B and PI3K/Akt Pathways.

Lee, Kyoung-Hee; Jang, An-Hee; Yoo, Chul-Gyu

17-Allylamino-17-Demethoxygeldanamycin and the Enhancement of PS-341-Induced Lung Cancer Cell Death by Blocking the NF-κB and PI3K/Akt Pathways.

Lee, Kyoung-Hee; Jang, An-Hee; Yoo, Chul-Gyu.

Afiliação

Lee KH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and Medical Research Center, Seoul National University College of Medicine, Seoul South Korea.
Jang AH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and Medical Research Center, Seoul National University College of Medicine, Seoul South Korea.
Yoo CG; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and Medical Research Center, Seoul National University College of Medicine, Seoul South Korea.

Am J Respir Cell Mol Biol ; 53(3): 412-21, 2015 Sep.

Article em En | MEDLINE | ID: mdl-25633180

Assuntos

Antineoplásicos/farmacologia; Benzoquinonas/farmacologia; Bortezomib/farmacologia; Lactamas Macrocíclicas/farmacologia; Neoplasias Pulmonares/tratamento farmacológico; Animais; Apoptose; Linhagem Celular Tumoral; Sinergismo Farmacológico; Humanos; Quinase I-kappa B/metabolismo; Quinases Associadas a Receptores de Interleucina-1/metabolismo; Camundongos Endogâmicos BALB C; Camundongos Nus; NF-kappa B/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteólise; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

17-AAG; Akt; GSK-3ß; NF-κB; PS-341

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzoquinonas / Lactamas Macrocíclicas / Bortezomib / Neoplasias Pulmonares / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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