Detection of DNA mismatch repair (MMR) deficiencies by immunohistochemistry can effectively diagnose the microsatellite instability (MSI) phenotype in endometrial carcinomas.

McConechy, M K; Talhouk, A; Li-Chang, H H; Leung, S; Huntsman, D G; Gilks, C B; McAlpine, J N

McConechy, M K; Talhouk, A; Li-Chang, H H; Leung, S; Huntsman, D G; Gilks, C B; McAlpine, J N.

Afiliação

McConechy MK; Department of Pathology and Laboratory Medicine, University of British Columbia and BC Cancer Agency, 509-2660 Oak Street, Vancouver V6H 3Z6, BC, Canada.
Talhouk A; Department of Pathology and Laboratory Medicine, University of British Columbia and BC Cancer Agency, 509-2660 Oak Street, Vancouver V6H 3Z6, BC, Canada.
Li-Chang HH; Department of Pathology and Laboratory Medicine, University of British Columbia and BC Cancer Agency, 509-2660 Oak Street, Vancouver V6H 3Z6, BC, Canada.
Leung S; Genetic Pathology Evaluation Centre, Department of Pathology and Laboratory Medicine, University of British Columbia, 509-2660 Oak Street, Vancouver V6H 3Z6, BC, Canada.
Huntsman DG; Department of Pathology and Laboratory Medicine, University of British Columbia and BC Cancer Agency, 509-2660 Oak Street, Vancouver V6H 3Z6, BC, Canada.
Gilks CB; Department of Pathology and Laboratory Medicine, University of British Columbia and BC Cancer Agency, 509-2660 Oak Street, Vancouver V6H 3Z6, BC, Canada.
McAlpine JN; Department of Gynecology and Obstetrics, Division of Gynecologic Oncology, University of British Columbia, 2775 Laurel St. 6th Floor, Vancouver V5Z 1M9, BC, Canada. Electronic address: jessica.mcalpine@vch.ca.

Gynecol Oncol ; 137(2): 306-10, 2015 May.

Article em En | MEDLINE | ID: mdl-25636458

Assuntos

Reparo de Erro de Pareamento de DNA; Neoplasias do Endométrio/genética; Instabilidade de Microssatélites; Proteínas Adaptadoras de Transdução de Sinal/genética; Adenosina Trifosfatases/genética; Biomarcadores Tumorais/genética; Estudos de Coortes; Enzimas Reparadoras do DNA/genética; Proteínas de Ligação a DNA/genética; Neoplasias do Endométrio/patologia; Feminino; Humanos; Imuno-Histoquímica; Pessoa de Meia-Idade; Endonuclease PMS2 de Reparo de Erro de Pareamento; Proteína 1 Homóloga a MutL; Proteína 2 Homóloga a MutS/genética; Proteínas Nucleares/genética; Fenótipo

Palavras-chave

Endometrial cancer; Lynch syndrome; Microsatellite instability; Mismatch repair

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Endométrio / Instabilidade de Microssatélites / Reparo de Erro de Pareamento de DNA Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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