A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase.
Diabetologia
; 58(4): 654-65, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25643653
ABSTRACT
The interactions between c-Kit and its ligand, stem cell factor (SCF), play an important role in haematopoiesis, pigmentation and gametogenesis. c-Kit is also found in the pancreas, and recent studies have revealed that c-Kit marks a subpopulation of highly proliferative pancreatic endocrine cells that may harbour islet precursors. c-Kit governs and maintains pancreatic endocrine cell maturation and function via multiple signalling pathways. In this review we address the importance of c-Kit signalling within the pancreas, including its profound role in islet morphogenesis, islet vascularisation, and beta cell survival and function. We also discuss the impact of c-Kit signalling in pancreatic disease and the use of c-Kit as a potential target for the development of cell-based and novel drug therapies in the treatment of diabetes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Ilhotas Pancreáticas
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Fator de Células-Tronco
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Proteínas Proto-Oncogênicas c-kit
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Diabetes Mellitus
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Células Secretoras de Insulina
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article